Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling

Valentina Botero, Jenifer Barrios, Anneke Knauss, Greta Dahlen, Ethan Rosendahl, Kenneth J. Colodner, Seth M. Tomchik

PLOS Genetics: published March 5, 2026 | https://doi.org/10.1371/journal.pgen.1012061

Transcriptional repression of reaper by Stand still ensures female germline development in Drosophila

Masaya Matsui, Shinichi Kawaguchi, Toshie Kai

PLOS Genetics: published March 5, 2026 | https://doi.org/10.1371/journal.pgen.1012041

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1. Correction: Transcriptional repression of reaper by Stand still ensures female germline development in Drosophila

PARP-2 catalytic activity drives replication-ICL repair in an allele-specific manner during germline development

Xiaojing Ren, Anna Hu, Zifei Liu, Semin Kim, Hyun-Min Kim

PLOS Genetics: published March 5, 2026 | https://doi.org/10.1371/journal.pgen.1012062

Alanine-scanning mutagenesis library of MreB reveals distinct roles for regulating cell shape and viability

Suman Maharjan, Ryan Sloan, Jada Lusk, Rose Bevienguevarr, Jacob Surber, Randy M. Morgenstein

PLOS Genetics: published March 9, 2026 | https://doi.org/10.1371/journal.pgen.1012070

Polygenic risk scores and Parkinson’s disease in South Africa advancing ancestry informed disease prediction

Kathryn Step, Carene Anne Alene Ndong Sima, Spencer Grant, Jonggeol Jeffrey Kim, Emily Waldo, Soraya Bardien, Ignacio F. Mata, on behalf of the Global Parkinson’s Genetics Program (GP2)

PLOS Genetics: published March 9, 2026 | https://doi.org/10.1371/journal.pgen.1012064

The effect of long-range linkage disequilibrium on allele-frequency dynamics under stabilizing selection

Sherif Negm, Carl Veller

PLOS Genetics: published March 9, 2026 | https://doi.org/10.1371/journal.pgen.1012035

The genetic basis of mimicry in the snowy bumble bee (Bombus niveatus) in Anatolia with insights from a color polymorphic gynandromorph

Tunç Dabak, Çiğdem Özenirler, Ece Kamalak, Cecil Smith, Seçil Aytekin, Ahmet Murat Aytekin, Heather M. Hines

PLOS Genetics: published March 11, 2026 | https://doi.org/10.1371/journal.pgen.1012060

Homeodomain protein Sxi1α independently controls cell-cell fusion and gene expression during sexual reproduction in Cryptococcus deneoformans

Jun Huang, Anna E. Lehmann, Patricia P. Peterson, Ziyan Xu, Liping Xiong, Sheng Sun, Joseph Heitman

PLOS Genetics: published March 12, 2026 | https://doi.org/10.1371/journal.pgen.1012084

Unraveling the genetic links between stature and disease in East Asians: A multi-biobank genetic correlation and risk prediction study

Ying-Ju Lin, Ting-Yuan Liu, Jai-Sing Yang, Ju-Pi Li, Jian-Shiun Chiou, Hsing-Fang Lu, Kuyuri Ariyoshi, Keiko Hikino, Chikashi Terao, Chen-Hsing Chou, Wen-Miin Liang, I-Ching Chou, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Fuu-Jen Tsai

PLOS Genetics: published March 13, 2026 | https://doi.org/10.1371/journal.pgen.1012030

Nucleosome positioning shapes cryptic antisense transcription

Jian Yi Kok, Zachary H. Harvey, Elin Axelsson, Frédéric Berger

PLOS Genetics: published March 13, 2026 | https://doi.org/10.1371/journal.pgen.1012078

COG5 deficiency disrupts cellular copper homeostasis and underlies the impaired mitochondrial OXPHOS function

Yuwei Zhou, Keyi Li, Ruowei Zhu, Xue Ma, Xinfei Ye, Mengqing Mao, Ding Li, Xiaofei Zeng, Zhehui Chen, Jing Wu, Liqin Jin, Xiaohua Tang, Yanling Yang, Jianxin Lyu, Xiaoting Lou

PLOS Genetics: published March 13, 2026 | https://doi.org/10.1371/journal.pgen.1012076

Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains

Claire J. LeBlanc, Jordan Stefani, Melvin Soriano, Angelica W. Y. Lam, Marissa A. Zintel, Sanjana R. Kotha, Emily P. Chase, Giovani Pimentel-Solorio, Aditya Vunnum, Gean Hu, Katherine L. Flug, Aaron Fultineer, Niklas Hummel, Max V. Staller

PLOS Genetics: published March 16, 2026 | https://doi.org/10.1371/journal.pgen.1012069

Topological stratification of continuous genetic variation in large biobanks

Alex Diaz-Papkovich, Shadi Zabad, Hannah Snell, Chief Ben-Eghan, Luke Anderson-Trocmé, Georgette Femerling, Vikram Nathan, Jenisha Patel, Simon Gravel

PLOS Genetics: published March 16, 2026 | https://doi.org/10.1371/journal.pgen.1012068

Estimating the distribution of fitness effects of loss of heterozygosity (LOH) events using an engineered library of Saccharomyces cerevisiae

Yi-Hong Ke, Michelle Orozco-Quime, Josh Bauman, Tamilie Carvalho, Grant A. Landry, Shuhua Ge, Anuj Kumar, Timothy Y. James

PLOS Genetics: published March 16, 2026 | https://doi.org/10.1371/journal.pgen.1012083

Simplifying causal gene identification in GWAS loci

Marijn Schipper, Jacob Ulirsch, Danielle Posthuma, Stephan Ripke, Karl Heilbron

PLOS Genetics: published March 17, 2026 | https://doi.org/10.1371/journal.pgen.1012079

Mechanistic dissection of GRHL2 and PR transcriptional co-regulation in breast cells

Marleen T. Aarts, Anna Nordin, Claudio Cantù, Antonius L. van Boxtel, Renée van Amerongen

PLOS Genetics: published March 17, 2026 | https://doi.org/10.1371/journal.pgen.1012088

Machine learning identifies novel signatures of antifungal drug resistance in Saccharomycotina yeasts

Marie-Claire Harrison, David C. Rinker, Abigail L. LaBella, Dana A. Opulente, John F. Wolters, Xiaofan Zhou, Xing-Xing Shen, Marizeth Groenewald, Chris Todd Hittinger, Antonis Rokas

PLOS Genetics: published March 17, 2026 | https://doi.org/10.1371/journal.pgen.1012091

Functional interrogation of candidate cis-regulatory elements at the LDLR locus

Kyle Leix, Candilianne Serrano-Zayas, Hitarthi S. Vyas, Sarah E. Graham, Brian T. Emmer

PLOS Genetics: published March 17, 2026 | https://doi.org/10.1371/journal.pgen.1012082

Plagl1 regulates the retinal progenitor cell to Müller glial cell transition

Yacine Touahri, Alissa Pak, Luke Ajay David, Joseph Hanna, Hedy Liu, Yucheng Xiao, Lauren Belfiore, Yaroslav Ilnytskyy, Edwin van Oosten, Nobuhiko Tachibana, Lata Adnani, Jiayi Zhao, Mary Hoffman, Rajiv Dixit, Dawn Zinyk, Cynthia J. Guidos, Volker Enzmann, Pengpeng Bi, Isabelle Aubert, Laurent Journot, Igor Kovalchuk, Yves Sauvé, Jeff Biernaskie, Chao Wang, Satoshi Okawa, Antonio del Sol, Carol Schuurmans

PLOS Genetics: published March 18, 2026 | https://doi.org/10.1371/journal.pgen.1012020

A scaffold attachment factor PHM-2 regulates synaptic transmission through SLO-2 potassium channel in C. elegans

Longgang Niu, Karthika Murugasen, Shannon Hanggodo, Sakia Ferdousy, Lishuang Zhu, Bojun Chen

PLOS Genetics: published March 19, 2026 | https://doi.org/10.1371/journal.pgen.1011962

An evaluation of age-varying genetic effects underlying body-mass index and blood pressure in the UK Biobank

Genevieve M. Leyden, Panagiota Pagoni, Grace M. Power, David Carslake, Tom G. Richardson, Kate Tilling, Gibran Hemani, George Davey Smith, Eleanor Sanderson

PLOS Genetics: published March 20, 2026 | https://doi.org/10.1371/journal.pgen.1012080

Genetic and functional characterization of AMH Signaling in Zebrafish - Evidence for Roles of Amh-Bmpr2a-Bmpr1bb Pathway in Controlling Gonadal Homeostasis

Yiming Yue, Chu Zeng, Xin Zhang, Chao Bian, Zhiwei Zhang, Kun Wu, Weiting Chen, Xianqing Zhou, Ling Lu, Nana Ai, Wei Ge

PLOS Genetics: published March 23, 2026 | https://doi.org/10.1371/journal.pgen.1011958

mTOR signaling regulates demand-adapted hematopoiesis and metabolic reprogramming required for an effective cellular immune response in Drosophila melanogaster larvae

Ines Anderl, Jens-Ola Ekström, Tea Tuomela, Mika Rämet, Tiina Susanna Salminen, Laura Vesala

PLOS Genetics: published March 24, 2026 | https://doi.org/10.1371/journal.pgen.1012094

Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans

Maddy Comerford, Davide M. Vespasiani, Navya Shukla, Laura E. Cook, Danat Yermakovich, Michael Dannemann, Matthew Leavesley, Christopher Kinipi, François-Xavier Ricaut, Nicolas Brucato, Murray P. Cox, Irene Gallego Romero

PLOS Genetics: published March 24, 2026 | https://doi.org/10.1371/journal.pgen.1012067

Post-translational modifications of GlmR integrate metabolic and stress signals to maintain cell envelope homeostasis in Bacillus subtilis

Logan B. Suits, Sebastian J. Khan, Dipanwita Bhattacharya, Silviya Dimitrova, Prahathees J. Eswara

PLOS Genetics: published March 30, 2026 | https://doi.org/10.1371/journal.pgen.1012096

Mms4 chromosomal association reveals functional relationships between meiotic crossover pathways in budding yeast

Amamah Farzlin Farnaz, Sameer Joshi, Praseetha Sarath, Girija Jogwar, Koodali T. Nishant

PLOS Genetics: published March 30, 2026 | https://doi.org/10.1371/journal.pgen.1012097

Characterization of EOP-1 reveals cell autonomous oscillations preceding somatic cell fusion in Neurospora crassa

Anne Geertje Oostlander, Marcel René Schumann, Lina Strzelczyk, Lucas Well, Ulrike Brandt, Marco Leiterholt, Stefan Jakschies, Tina Rietschel, Josef Wissing, Lothar Jänsch, André Fleißner

PLOS Genetics: published March 31, 2026 | https://doi.org/10.1371/journal.pgen.1012087

The adapt-to-nutrient NRPS-like secondary metabolite gene cluster facilitates Verticillium dahliae adaptation to different nutrient environments

Ying-Yu Chen, Lea S. Steglich, Nadja Spasovski, Marcel H. W. Franzius, Merle Aden, Isabel Maurus, Rebekka Harting, Gerhard H. Braus

PLOS Genetics: published March 31, 2026 | https://doi.org/10.1371/journal.pgen.1011930

Correction: How convincing is a matching Y-chromosome profile?

Mikkel M. Andersen, David J. Balding

PLOS Genetics: published March 30, 2026 | https://doi.org/10.1371/journal.pgen.1012099

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Wanted: A population genetic theory of biological noise regulation

Daniel M. Weinreich, Tom Sgouros, Yevgeniy Raynes, Hlib Burtsev, Edison Chang, Sanyu Rajakumar, Ignacio G. Bravo, Csenge Petak

PLOS Genetics: published March 13, 2026 | https://doi.org/10.1371/journal.pgen.1012066